| Autor: |
Vasiliki Vartela, Iakovos Armenis, Dimitra Leivadarou, Konstantinos Toutouzas, Konstantinos Makrilakis, George D. Athanassopoulos, George Karatasakis, Genovefa Kolovou, Sophia Mavrogeni, Despina Perrea |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
International Journal of Cardiology. Hypertension, Vol 9, Iss , Pp 100083- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2590-0862 |
| DOI: |
10.1016/j.ijchy.2021.100083 |
| Popis: |
Background: Heterozygous familial hypercholesterolemia (heFH) is a genetic disorder leading to premature coronary artery disease (CAD). We hypothesized that the subclinical pathophysiologic consequences of hypercholesterolemia may be detected before the occurrence of clinically overt CAD by stress testing and myocardial strain imaging. Patients-methods: We evaluated the treadmill tests (ETTs) of 46 heFH men without known arterial hypertension/diabetes mellitus/vasculopathy like CAD and of 39 healthy men matched for age, baseline systolic/diastolic blood pressure (BP) and heart rate (HR), using Bruce protocol. Global longitudinal strain (GLS) of the left ventricle (LV) additionally to ejection fraction was obtained. Results: heFH men reached a significantly higher peak systolic and diastolic BP compared to controls (p = 0.002 and p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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