Mental and Growth Retardation following Prenatal Exposure to Oral Bitter Leaf (Vernonia amygdalina) Extract in Developing Wistar Rats
| Autor: | Balogun Wasiu Gbolahan, Gbadeyan Temitope Ruth, Ishola Azeez Olakunle, Atoyebi Aminat Temitayo, Cobham Ansa Emmanuel, Enaibe Bernard Ufuoma |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Journal of the Dow University of Health Sciences, Vol 9, Iss 2, Pp 43-47 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1995-2198 2410-2180 |
| Popis: | Objective: The teratogenic influence of maternal exposure to bitter leaf on the morphology of foetal nervoussystem was studied. Methodology: In this study, we used twenty five pristine female Wistar rats of an average weight of 215g.The rats were distributed into 5 groups with each having 5 rats. A separate cage was used to keep each group.Overnight, the females were kept with sexually active male of the same species. The following morning,Vagina smears was done on the female to confirm coitus, the presence of tailed structures in the smears wastaken as sperm positive day and was taken as day zero of pregnancy. 400mg/kg of bitter leaf were administeredorally between gestational days 1-7 (group B), 8-14 (group C), 15-21 (group D) and 1-21 (group E). Thecontrol (group A) was administered 2.0ml/kg/bw of normal saline throughout pregnancy. After parturition,the brain and body weights of the litters were recorded on postnatal days 1, 7, 14, 21, 28 and 35. Results: Results show that the litters of the group C and E demonstrated significant (p < 0.05) reduction inall parameters measured when compared to the control and the group B and D. The foetal weight and brainweight decreased significantly (p |
| Databáze: | Directory of Open Access Journals |
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