| Autor: |
Nina S. Nikolova, Krasimir Antonov, Deian Jelev, Lyudmila Mateva, Zahariy Krastev |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Journal of IMAB, Vol 19, Iss 3, Pp 442-447 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1312-773X |
| DOI: |
10.5272/jimab.2013193.442 |
| Popis: |
Introduction: IP-10 it has been studied as a predictor of treatment response in chronic HCV infected patients. The data for the HBV infection are not enough.Aim: To compare IP-10 levels in patients with chronic HBV /CHB/ and HCV infection /CHC/ and their relation to liver disease and treatment response. Material and methods: 20 patients - with CHC genotype 1 infection /on standard bi-therapy/ and 32 patients with CHB /21 pts - NUC; 11 pts - IFN/. Results: The IP-10 did not correlate with sex, age, ALT and liver fibrosis. The basal IP-10 were lower in patients with CHB (p=0,017). There was a difference in IP-10 baseline levels among the HCV patients with or without RVR (p=0,007). A negative correlation was found between basal IP-10 and RVR (r= -0,508; p=0,008). Conclusion: IP-10 could predict virological response in patients with CHC on standard bi-therapy, but not in HBV infected patients on standard therapy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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