Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis

Autor:	Alyria Teixeira Dias, Sandra Bertelli Ribeiro de Castro, Caio César Souza Alves, Alice Belleigoli Rezende, Michele Fernandes Rodrigues, Rachel Rocha Pinheiro Machado, Adriana Fernandes, Deborah Negrão-Corrêa, Henrique Couto Teixeira, Ana Paula Ferreira
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	M. bovis S. venezuelensis coinfection IL-17 CTLA-4 - tuberculosis Microbiology QR1-502 Infectious and parasitic diseases RC109-216
Zdroj:	Memorias do Instituto Oswaldo Cruz, Vol 106, Iss 5, Pp 617-619 (2011)
Druh dokumentu:	article
ISSN:	1678-8060 0074-0276
DOI:	10.1590/S0074-02762011000500015
Popis:	The presence of intestinal helminths can down-regulate the immune response required to control mycobacterial infection. BALB/c mice infected with Mycobacterium bovis following an infection with the intestinal helminth Strongyloides venezuelensis showed reduced interleukin-17A production by lung cells and increased bacterial burden. Also, small granulomas and a high accumulation of cells expressing the inhibitory molecule CTLA-4 were observed in the lung. These data suggest that intestinal helminth infection could have a detrimental effect on the control of tuberculosis (TB) and render coinfected individuals more susceptible to the development of TB.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/657f7dc088ff42ebbffc4e82eeda42bc Zobrazit plný text záznamu View record in DOAJ