| Autor: |
Ruba Yehia, Iqbal M. Lone, Ibrahim Yehia, Fuad A. Iraqi |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Phytomedicine Plus, Vol 3, Iss 1, Pp 100394- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2667-0313 |
| DOI: |
10.1016/j.phyplu.2022.100394 |
| Popis: |
Background: Portulaca oleracea L. (PO) is a herb widely used in folk medicine as antioxidant and mainly as an anti-diabetic. However, scientific evidence of its effects remains very limited. Here we aim to unravel the effect of the host genetic background on the PO treatment in the development of obesity and type 2 diabetes (T2D) using the genetically diverse Collaborative Cross (CC) mouse model, which could contribute to better understand and design personalized medical treatment. Results: We have studied the PO treatments efficacy on reduction of body weight (BW) and glucose tolerance ability in 221 mice of 13 different CC lines as a response to two different diets: the control match diet (CMD – 10% fat) as a control group and the high-fat diet (HFD – 60% fat) as the experiment group. Glucose tolerance ability was determined by a 180 minutes Intraperitoneal Glucose Tolerance Test (IPGTT) and the calculation of the area under the curve (AUC) was made. PO treatments started in week 12 of the dietary challenge and lasted for 4 weeks. PO was given to the mice every other day by intraperitoneal (IP) injection at concentration of 200mg/kg. The results showed significant sex effect across the different lines and assessed traits; therefore, male and female mice data was analyzed separately. Sex differences among lines were analyzed by ANOVA and shown to be significant (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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