Sexual dimorphism of monocyte transcriptome in individuals with chronic low-grade inflammation

Autor: Jisun So, Albert K. Tai, Alice H. Lichtenstein, Dayong Wu, Stefania Lamon-Fava
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Biology of Sex Differences, Vol 12, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 2042-6410
DOI: 10.1186/s13293-021-00387-y
Popis: Abstract Sexual dimorphism in the immune system is evidenced by a higher prevalence of autoimmune diseases in women and higher susceptibility to infectious diseases in men. However, the molecular basis of these sex-based differences is not fully understood. We have characterized the transcriptome profiles of peripheral blood monocytes from males and postmenopausal females with chronic low-grade inflammation. We identified 41 sexually differentially expressed genes [adjusted p value (FDR)
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