Modified EPOCH for high‐risk non‐Hodgkin lymphoma in sub‐Saharan Africa

Autor: Takondwa Zuze, Grace K. Ellis, Edwards Kasonkanji, Bongani Kaimila, Richard Nyasosela, Ruth Nyirenda, Tamiwe Tomoka, Maurice Mulenga, Maria Chikasema, Blessings Tewete, Asekanadziwa Mtangwanika, Sarah Chiyoyola, Fred Chimzimu, Coxcilly Kampani, Wilberforce Mhango, Simon Nicholas, Cara Randall, Nathan D. Montgomery, George Fedoriw, Katherine D. Westmoreland, Matthew S. Painschab, Satish Gopal
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Cancer Medicine, Vol 9, Iss 1, Pp 77-83 (2020)
Druh dokumentu: article
ISSN: 2045-7634
DOI: 10.1002/cam4.2631
Popis: Abstract Aggressive non‐Hodgkin lymphoma (NHL) is among the most common cancers in sub‐Saharan Africa (SSA), where CHOP is standard treatment and outcomes are poor. To address this, we treated 17 newly diagnosed adult patients in Malawi with Burkitt (n = 8), plasmablastic (n = 8), and primary effusion lymphoma (n = 1) with a modified EPOCH regimen between 2016 and 2019. Twelve patients (71%) were male and the median age was 40 years (range 16‐63). Eleven (65%) were HIV infected, median CD4 count was 218 cells/µL (range 9‐460), and nine (82%) had suppressed HIV RNA
Databáze: Directory of Open Access Journals
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