| Autor: |
Michael J. Dubec, Michael Berks, James Price, Lisa McDaid, John Gaffney, Ross A. Little, Susan Cheung, Marcel van Herk, Ananya Choudhury, Julian C. Matthews, Andrew McPartlin, Geoff J.M. Parker, David L. Buckley, James P.B. O’Connor |
| Jazyk: |
angličtina |
| Rok vydání: |
2025 |
| Předmět: |
|
| Zdroj: |
Physics and Imaging in Radiation Oncology, Vol 33, Iss , Pp 100689- (2025) |
| Druh dokumentu: |
article |
| ISSN: |
2405-6316 |
| DOI: |
10.1016/j.phro.2024.100689 |
| Popis: |
Background and purpose: Magnetic resonance imaging – linear accelerator (MRI-linac) systems permit imaging of tumours to guide treatment. Dynamic contrast enhanced (DCE)-MRI allows investigation of tumour perfusion. We assessed the feasibility of performing DCE-MRI on a 1.5 T MRI-linac in patients with head and neck cancer (HNC) and measured biomarker repeatability and sensitivity to radiotherapy effects. Materials and methods: Patients were imaged on a 1.5 T MRI-linac or a 1.5 T diagnostic MR system twice before treatment. DCE-MRI parameters including Ktrans were calculated, with the optimum pharmacokinetic model identified using corrected Akaike information criterion. Repeatability was assessed by within-subject coefficient of variation (wCV). Treatment effects were assessed as change measured at week 2 of radiotherapy. Results: 14 patients were recruited (6 scanned on diagnostic MR and 8 on MRI-linac), with a total of 24 lesions. Baseline Ktrans estimates were comparable on both MR systems; 0.13 [95 %CI: 0.10 to 0.16] min−1 (diagnostic MR) and 0.15 [0.12 to 0.18] min−1 (MRI-linac). wCV values were 22.6 % [95 % CI: 16.2 to 37.3 %] (diagnostic MR) and 11.7 % [8.4 to 19.3 %] (MRI-linac). Combined cohort increase in Ktrans was significant (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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