Melatonin Levels in Serum and Ascitic Fluid of Patients with Hepatic Encephalopathy
| Autor: | Cezary Chojnacki, Marek Romanowski, Katarzyna Winczyk, Janusz Błasiak, Jan Chojnacki |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Gastroenterology Research and Practice, Vol 2012 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1687-6121 1687-630X |
| DOI: | 10.1155/2012/510764 |
| Popis: | Cirrhotic patients exhibit disturbed melatonin homeostasis, which may lead to sleep disturbances, but an influence on the hepatic encephalopathy has not been elucidated. Aim. In the present study, the association of melatonin levels in serum and ascitic fluid and ammonia concentration related to the intensity of hepatic encephalopathy (HE) was investigated. Material and Methods. The study included 90 alcoholic patients with hepatic encephalopathy and 30 healthy volunteers (C). Patients were divided in three groups according to 0–4 West-Haven Score: HE1 (n=28), HE2 (n=30), and HE3 (n=32). Melatonin was measured by radioimmune assay. Results. In fasting patients with hepatic encephalopathy we noted higher melatonin serum levels [pg/mL] than in healthy subjects groups: C—11.3 ± 3.9, HE1 – 34.3 ± 12.2 (P |
| Databáze: | Directory of Open Access Journals |
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