Clinical manifestations of chronic pancreatitis in English cocker spaniels
Autor: | M. Francisca Coddou, Barbara Blacklaws, Penny J. Watson |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2024 |
Předmět: | |
Zdroj: | Journal of Veterinary Internal Medicine, Vol 38, Iss 4, Pp 2129-2137 (2024) |
Druh dokumentu: | article |
ISSN: | 1939-1676 0891-6640 |
DOI: | 10.1111/jvim.17100 |
Popis: | Abstract Background Chronic pancreatitis (CP) is common in English cocker spaniels (ECS). It is histologically similar to IgG4‐related disease (IgG4‐RD) in humans and is characterized by duct destruction, interlobular fibrosis, and dense periductular and perivenous lymphocytic aggregates. However, the clinical manifestations of CP in ECS have not been previously described. Objectives Characterize the clinical manifestations of CP in a group of ECS, including similarities and differences to IgG4‐RD in humans. Animals One‐hundred four ECS with CP and 44 client owned control ECS without CP (both healthy and diseased controls). Methods Affected dogs were divided into 2 groups according to the methods used to diagnose CP. Case records were searched for signalment, clinical, and clinicopathological findings, and evidence of keratoconjunctivitis sicca (KCS), proteinuria, other immune‐mediated diseases, and anal sacculitis. Results Involvement of other organs was common. Affected ECS presented with a high frequency of KCS (n = 49), proteinuria (n = 47), anal gland disease (n = 36), atopy (n = 21), and other immune‐mediated diseases (n = 16). Those with parti‐color hair coats, particularly blue roan, had a strong association with CP, suggesting a link between coat color and autoimmune conditions in this breed. Conclusions and Clinical Importance English cocker spaniels with CP show clinical similarities to humans with IgG4‐RD and common involvement of other organs. Clinicians should evaluate affected Cocker Spaniels for proteinuria, keratoconjunctivitis sicca, and other potential immune‐mediated diseases. |
Databáze: | Directory of Open Access Journals |
Externí odkaz: |