Direct Modification of Extracellular Vesicles and Its Applications for Cancer Therapy: A Mini-Review

Autor: Wenbin Nan, Chao Zhang, Hao Wang, Hongli Chen, Shenglu Ji
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Chemistry, Vol 10 (2022)
Druh dokumentu: article
ISSN: 2296-2646
DOI: 10.3389/fchem.2022.910341
Popis: Extracellular vesicles (EVs) are a class of lipid membrane-bound vesicles released by various cells and mediate cell-to-cell communication. By reason of their high physiochemical stability and biocompatibility, EVs are considered as novel drug delivery system. An increasing number of studies have indicated that EVs can be modified to enhance their loading efficiency, targeting ability and therapeutic capabilities for cancer therapy. Compared with the tedious process of gene engineering approaches, direct modification of EVs is easier, faster and versatile. This mini review will summarize the prevailing approaches for direct modification of EVs. Additionally, the potential applications of modified EVs in cancer therapy are also discussed, which will help readers gain a better understanding of the technologies and applications in this field.
Databáze: Directory of Open Access Journals