Unravelling cell migration: defining movement from the cell surface
| Autor: | Francisco Merino-Casallo, Maria Jose Gomez-Benito, Silvia Hervas-Raluy, Jose Manuel Garcia-Aznar |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Cell Adhesion & Migration, Vol 16, Iss 1, Pp 25-64 (2022) |
| Druh dokumentu: | article |
| ISSN: | 19336918 1933-6926 1933-6918 04717937 |
| DOI: | 10.1080/19336918.2022.2055520 |
| Popis: | Cell motility is essential for life and development. Unfortunately, cell migration is also linked to several pathological processes, such as cancer metastasis. Cells’ ability to migrate relies on many actors. Cells change their migratory strategy based on their phenotype and the properties of the surrounding microenvironment. Cell migration is, therefore, an extremely complex phenomenon. Researchers have investigated cell motility for more than a century. Recent discoveries have uncovered some of the mysteries associated with the mechanisms involved in cell migration, such as intracellular signaling and cell mechanics. These findings involve different players, including transmembrane receptors, adhesive complexes, cytoskeletal components , the nucleus, and the extracellular matrix. This review aims to give a global overview of our current understanding of cell migration. |
| Databáze: | Directory of Open Access Journals |
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