CSF synaptic protein concentrations are raised in those with atypical Alzheimer’s disease but not frontotemporal dementia

Autor:	Mica T. M. Clarke, Ann Brinkmalm, Martha S. Foiani, Ione O. C. Woollacott, Carolin Heller, Amanda Heslegrave, Ashvini Keshavan, Nick C. Fox, Jonathan M. Schott, Jason D. Warren, Kaj Blennow, Henrik Zetterberg, Jonathan D. Rohrer
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Alzheimer’s disease Frontotemporal dementia Synaptic Biomarkers Neurogranin SNAP-25 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Zdroj:	Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-9 (2019)
Druh dokumentu:	article
ISSN:	1758-9193 65293029
DOI:	10.1186/s13195-019-0564-2
Popis:	Abstract Background Increased CSF levels of a number of synaptic markers have been reported in Alzheimer’s disease (AD), but little is known about their concentrations in frontotemporal dementia (FTD). We investigated this in three synaptic proteins, neurogranin, SNAP-25, and synaptotagmin-1. Methods CSF samples were analysed from 66 patients with a disorder in the FTD spectrum and 19 healthy controls. Patients were stratified by their tau to Aβ42 ratio: those with a ratio of > 1 considered as having likely AD pathology, i.e. an atypical form of AD (‘AD biomarker’ group [n = 18]), and
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/652930293ccf4a4792d1a9b6d432378e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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