Voltammetric behavior and determination of the bronchodilator doxofylline at a boron-doped diamond electrode
| Autor: | Sachin Saxena, Ratnanjali Shrivastava, Soami P. Satsangee |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Macedonian Journal of Chemistry and Chemical Engineering, Vol 31, Iss 2 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1857-5552 1857-5625 |
| DOI: | 10.20450/mjcce.2012.42 |
| Popis: | The electrochemical behavior of the asthma drug doxofylline was studied at a boron-doped diamond electrode in BR buffer (pH 3.8) by square-wave voltammetry. Cyclic voltammetry revealed the oxidation of doxofylline as an irreversible diffusion-controlled process. The oxidation mechanism was proposed and the drug was studied in the presence of solubilized systems like Tween-20 (T-20), sodium dodecyl sulfate (SDS), Triton X-100 (TTN), dioxane (DO), dimethylformamide (DMF), diethyl ether (DEE), benzene and methanol (MeOH). Comparison of the current responses in the solution system explained the sensitivity of the boron-doped diamond electrode (BDDE) with a three-fold increase in the current value compared to that of a glassy carbon electrode (GCE) at a fixed concentration of doxofylline. Peak current values varied linearly with increasing concentration and the LOD and LOQ were found to be 3.48 and 10.56 µg/ml, respectively. This method was employed to investigate doxofylline in the pharmaceutical formulation. |
| Databáze: | Directory of Open Access Journals |
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