Epidemiological, Clinical, and Oncological Outcomes of non-Alcohol Drinking and non-Smoking Laryngeal Squamous Cell Carcinoma Patients: A Distinct Entity

Autor: Qiang Huang MD, Yang Guo MD, Yujie Shen MD, Chi-Yao Hsueh MD, Lei Tao MD, Ming Zhang MD, Chunping Wu MD, Hongli Gong MD, Liang Zhou MD
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Technology in Cancer Research & Treatment, Vol 21 (2022)
Druh dokumentu: article
ISSN: 1533-0338
15330338
DOI: 10.1177/15330338221133690
Popis: Purpose: To explore the discrepancy in clinicopathological and prognostic features between smoking and alcohol drinking (SA) and non-smoking and non-alcohol drinking (NSNA) patients with laryngeal squamous cell carcinoma (LSCC). Methods: This retrospective study including 1735 patients with LSCC was conducted from January 2005 to December 2010, which were categorized into 4 groups, NSNA group, smoking only group, alcohol-drinking only group, and SA group. We compared overall survival (OS) and disease-free survival (DFS) using the Kaplan–Meier method and indicated clinicopathological features by Cox proportional hazards regression models before and after propensity score matching (PSM). Results: A total of 415 patients (23.92%) were identified as NSNA. The SA group was predominantly patients ≤60 years old (46.63%) while the NSNA group was more older (58.07%). NSNA group was more likely to present at earlier disease stage and more female. No significant difference in OS ( P = .685) and DFS ( P = .976) was found between the 2 groups. In addition to age and recurrence and metastasis being common independent prognostic factors in terms of OS in both groups of patients, NSNA group also exhibited other factors, namely tumor area >3.7 cm 2 and positive resection margin. For DFS, N + stage, tumor size >3.7 cm 2 , and positive resection margin were prognostic features specific to NSNA group. Conclusion: The outcome is similar in LSCC patients with and without SA. NSNA group shows a distinct profile from that found in SA group. Clinicopathological features from NSNA group should be considered for LSCC management.
Databáze: Directory of Open Access Journals
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