| Autor: |
Ângela Cristine Bersch-Ferreira, Camila Weschenfelder, Rachel Helena Vieira Machado, Renato Hideo Nakagawa Santos, Terrence M. Riley, Lucas Ribeiro da Silva, Debora Harumi Kodama Miyada, Erica Regina Ribeiro Sady, Erlon Oliveira de Abreu-Silva, Ligia Nasi Laranjeira, Alexandre Schaan de Quadros, Júlia Lorenzon dos Santos, Gabriela Corrêa Souza, Suena Medeiros Parahiba, Ana Paula Trussardi Fayh, Danielle Soares Bezerra, Ana Paula Perillo Ferreira Carvalho, Malaine Morais Alves Machado, Sandra Mary Lima Vasconcelos, Mayranne Victórya Rocha Santos, José Albuquerque de Figueiredo Neto, Luciana Pereira Pinto Dias, Francisca Eugenia Zaina Nagano, Cássia Cristina Paes de Almeida, Annie Seixas Bello Moreira, Rodrigo Damasceno de Oliveira, Marcelo Macedo Rogero, Geni Rodrigues Sampaio, Elizabeth Aparecida Ferraz da Silva Torres, Bernardete Weber, Alexandre Biasi Cavalcanti, Aline Marcadenti |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Nutrition Journal, Vol 23, Iss 1, Pp 1-15 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1475-2891 |
| DOI: |
10.1186/s12937-024-01020-5 |
| Popis: |
Abstract Background Nuts consumption is related to cardioprotective effects on primary cardiovascular prevention, but studies conducted in secondary prevention are small, scarce and controversial. The objective of this trial was to evaluate the effects of a regional and sustainable cardioprotective diet added or not with an affordable mixed nuts on cardiometabolic features in patients with previous myocardial infarction. Methods DICA-NUTS study is a national, multi-center, and superiority-parallel randomized clinical trial. Males and females over 40 years old diagnosed with previous myocardial infarction in the last 2 to 6 months were included. Patients were allocated into two groups: the Brazilian Cardioprotective diet (DICA Br) supplemented with 30 g/day of mixed nuts (10 g of peanuts; 10 g of cashew; 10 g of Brazil nuts) (intervention group, n = 193); or only DICA Br prescription (control group, n = 195). The primary outcome was low-density lipoprotein cholesterol means (in mg/dL) after 16 weeks. Secondary outcomes were other lipid biomarkers, glycemic and anthropometric data and diet quality. Results After adjustment for baseline values, participating study site, time since myocardial infarction and statin treatment regimen (high potency, moderate and low potency/no statins), no significant difference was found between the groups in low-density lipoprotein cholesterol concentrations (intervention-control difference: 3.48 mg/dL [-3.45 to 10.41], P = 0.32). Both groups improved their overall diet quality at the end of the study without differences between them after 16 weeks (intervention-control difference: 1.05 (-0.9 to 2.99); P = 0.29). Other lipids, glycemic profile and anthropometrics were also not different between study groups at the end of the study. Conclusion Adding 30 g/day of mixed nuts to the DICA Br for 16 weeks did not change lipid, glycemic and anthropometric features in the post-myocardial infarction setting. Trial registration This study is registered on ClinicalTrials.gov website under number NCT03728127 and its World Health Organization Universal Trial Number (WHO-UTN) is U1111-1259–8105. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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