11, 13-Dehydro Lactone Moiety in Gynecologic Cancer Cells
| Autor: | Yibing LIU, Qingju MENG, Li JING, Li FENG, Zhiguo ZHOU, Zhiyu NI |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Iranian Journal of Public Health, Vol 49, Iss 11, Pp 2103-2110 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2251-6085 2251-6093 |
| DOI: | 10.18502/ijph.v49i11.4726 |
| Popis: | Background: To study the anti-cancer effect of isoalantolactone, a sesquiterpene lactoneisolated from the roots of Inula heleniumon human gynecologic cancer cells. Methods: A structure-activity relationship experiment was designed to identify the functional moiety of isoalantolactone for its significant anti-cancer activity. Five gynecologic cancer cell lines were treated with isoalantolactone. Cell proliferation was determined by MTT assay in vitro and cell apoptosis by flow cytometry. Results: We found isoalantolactone strongly inhibited the cell proliferationofHEC-1, HAC-2, HOC-21, and HeLa cells. Its inhibitory effect was comparable to that of well-known chemotherapeutic agents, cisplatin and taxol. Furthermore, isoalantolactone induced apoptosis in HeLa cells via caspase. On the contrary, its 11, 13-dihydro derivatives had much weaker anti-proliferative activities than the parent compound. Conclusion: Isoalantolactone exhibited strong anti-proliferative activities and apoptosis-inducing effects on gynecologic cancer cells. The 11, 13-dehydro lactone moiety was critical for its anti-proliferative activity. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|