| Autor: |
Yani Medina Lestari, Vita Murniati Tarawan, Achadiyani Achadiyani, Putri Teesa Radhiyanti, Hamidie Ronald Daniel Ray, Ronny Lesmana, Hanna Goenawan |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Physiological Reports, Vol 11, Iss 17, Pp n/a-n/a (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2051-817X |
| DOI: |
10.14814/phy2.15803 |
| Popis: |
Abstract Specific exercise intensities could improve lung vascular function by increasing nitric oxide (NO). The ACE2/MasR/eNOS axis is one of the pathways facilitating NO synthesis. This study examines the effect of different intensities of aerobic training on the ACE2/MasR/eNOS axis and histology of lung muscular arteries. Male Wistar rats were used in this study and randomized into control and exercise groups receiving low‐, moderate‐, and high‐intensity training. The training was conducted for 30 min daily, five times a week, for 8 weeks. We observed that different exercise intensities affect the ACE2/MasR/eNOS pathway differently. Compared to control, high‐intensity aerobic exercise significantly increased ACE2, Mas receptor (MasR), and eNOS mRNA expressions (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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