Human organ chips for regenerative pharmacology

Autor:	Girija Goyal, Chaitra Belgur, Donald E. Ingber
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	clinical predictivity intestine‐on‐a‐chip lung‐on‐a‐chip lymph Node‐on‐a‐chip microphysiological systems organs on chips Therapeutics. Pharmacology RM1-950
Zdroj:	Pharmacology Research & Perspectives, Vol 12, Iss 1, Pp n/a-n/a (2024)
Druh dokumentu:	article
ISSN:	2052-1707
DOI:	10.1002/prp2.1159
Popis:	Abstract Human organs‐on‐chips (organ chips) are small microfluidic devices that allow human cells to perform complex organ‐level functions in vitro by recreating multi‐cellular and multi‐tissue structures and applying in vivo‐like biomechanical cues. Human Organ Chips are being used for drug discovery and toxicology testing as an alternative to animal models which are ethically challenging and often do not predict clinical efficacy or toxicity. In this mini‐review, we summarize our presentation that reviewed the state of the art relating to these microfluidic culture devices designed to mimic specific human organ structures and functions, and the application of Organ Chips to regenerative pharmacology.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/65071d66b6624c21a0c7ca48268af975 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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