| Autor: |
Congcong Sun, Lixian Chang, Chao Liu, Xiaoyan Chen, Xiaofan Zhu |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Molecular Genetics & Genomic Medicine, Vol 7, Iss 10, Pp n/a-n/a (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2324-9269 |
| DOI: |
10.1002/mgg3.933 |
| Popis: |
Abstract Background This study was aimed to explore the METTL3 and METTL14 expressions in children with ETV6/RUNX1(E/R)‐positive acute lymphoblastic leukemia (ALL) and investigate the relation between the METTL3 and METTL14 expressions with clinical features. Methods Thirty‐seven newly diagnosed E/R‐positive ALL children and six controls were included in this study. Real‐time quantitative polymerase chain reaction (RT‐PCR) was used to detect the mRNA expression level of METTL3 and METTL14. Results Among the 37 cases, 51.35% (n = 19) were boys and 48.65% (n = 18) were girls and the median age was 4.72 (1.72–11.99) years. Among the six controls, 50% (n = 3) were boys and 50% (n = 3) were girls and the median age was 5.24 (1.53–13.17) years. The expression level of METTL3 and METTL14 in E/R‐positive ALL patients were lower than in controls (p |
| Databáze: |
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