Pioneering Synthetic Strategies of 2-Substituted Benzothiazoles Using 2-Aminothiophenol

Autor: Sunita Teli, Ayushi Sethiya, Shikha Agarwal
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Chemistry, Vol 6, Iss 1, Pp 165-206 (2024)
Druh dokumentu: article
ISSN: 2624-8549
DOI: 10.3390/chemistry6010009
Popis: Heterocycles, compounds featuring heteroatoms like nitrogen, sulfur, and oxygen, are integral in fields such as synthesis, pharmacology, and medicine. Among these, benzothiazoles, formed by fusing thiazole with benzene, hold significant prominence. Their unique reactivity, especially at the carbon position between nitrogen and sulfur, has sparked wide interest. Notably, 2-substituted benzothiazoles exhibit diverse biological activities, including anticonvulsant, antimicrobial, and antioxidant properties, making them valuable in drug discovery. This review unveils an array of mesmerizing methods employed by chemists to prepare these compounds using 2-aminothiophenol as one of the precursors with other varied reactants. From novel strategies to sophisticated methodologies, each section of this review provides a glimpse into the fascinating world of synthetic chemistry of 2-substituted benzothiazoles. Delving into the diverse synthetic applications of 2-substituted benzothiazoles, this paper not only enriches our understanding of their synthesis but also sparks the imagination with the possibilities for future advancements.
Databáze: Directory of Open Access Journals
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