Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted Therapy

Autor:	Shenthol Sasankan, Lorraine Rebuck, Gloria Darrah, Moises Harari Turquie, Ian Rabinowitz
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	braf mutation cancer biology gastrointestinal oncology pancreatic cancer targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncology, Vol 13, Iss 3, Pp 1239-1243 (2020)
Druh dokumentu:	article
ISSN:	1662-6575
DOI:	10.1159/000510096
Popis:	We report on the clinical history of a 49-year-old female with metastatic pancreatic cancer. She was initially treated with standard chemotherapy as per current guidelines. She was found to have both a BRAF and P53 mutation, and received dabrafenib and trametinib with deep responses, both radiographically and biochemically (CA19-9). Her response has been more clinically relevant than responses in previous case reports of patients with BRAF-positive pancreatic cancer treated with targeted therapy. To the best of our knowledge, this is the first case report showing a dramatic therapeutic response to combination therapy with dabrafenib and trametinib in metastatic pancreatic cancer.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/64f08a7e689d47d2902d3944f3acc21e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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