Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence

Autor: Haruka Toda, Miriam Diaz-Varela, Joan Segui-Barber, Wanlapa Roobsoong, Barbara Baro, Susana Garcia-Silva, Alicia Galiano, Melisa Gualdrón-López, Anne C. G. Almeida, Marcelo A. M. Brito, Gisely Cardoso de Melo, Iris Aparici-Herraiz, Carlos Castro-Cavadía, Wuelton Marcelo Monteiro, Eva Borràs, Eduard Sabidó, Igor C. Almeida, Jakub Chojnacki, Javier Martinez-Picado, Maria Calvo, Pilar Armengol, Jaime Carmona-Fonseca, Maria Fernanda Yasnot, Ricardo Lauzurica, Antonio Marcilla, Hector Peinado, Mary R. Galinski, Marcus V. G. Lacerda, Jetsumon Sattabongkot, Carmen Fernandez-Becerra, Hernando A. del Portillo
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-16337-y
Popis: Extracellular vesicles (EVs) in plasma can affect pathogenesis of parasites, but details remain unclear. Here, Toda et al. characterize plasma-derived EVs from Plasmodium vivax patients and show that PvEVs are preferentially taken up by human spleen fibroblasts, facilitating parasite cytoadherence.
Databáze: Directory of Open Access Journals