More Evidence of the Link of Interleukin-6 and Interleukin-10 with Critical COVID-19: A Report in Mexican Patients
| Autor: | German Jiménez-Gastélum, Arely Espinoza-Ortega, Rosalío Ramos-Payán, Maribel Aguilar-Medina, Jorge López-Gutiérrez, Carlos Villegas-Mercado, Luis Ochoa-Ramirez, Horacio Rendón-Aguilar, Juan Osuna-Ramos, Juan Ríos-Tostado, Jesús Velarde-Félix |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Iranian Journal of Immunology, Vol 18, Iss 4, Pp 331-337 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1735-1383 1735-367X |
| DOI: | 10.22034/iji.2021.89905.1978 |
| Popis: | Background: According to the World Health Organization, Mexico presents one of the highest mortality rates due to coronavirus disease 2019 (COVID-19). The "cytokine storm" phenomenon has been proposed as a pathological hallmark of severe COVID-19. Objective: To determine the association of serum cytokine levels with COVID-19 severity. Methods: We studied the cytokines IL-2, IL-4, IL-6, IL-10, TNF-α, and the IFN-γ serum levels through flow cytometry in 56 COVID-19 patients (24 critical and 32 non-critical) from Northwest Mexico. Results: We observed a significant increase in the IL-6 and the IL-10 levels in the sera of critical patients. These cytokines were also associated with mechanical ventilation necessity and death, IL-6 showing AUC values above 0.7 for both variables; and correlated with Na+, creatinine, and platelet levels. On the other hand, no association was found between IL-2, IL-4, TNF-α, and IFN-γ with tested variables. Conclusion: Our results corroborate previous observations regarding IL-6 and IL-10 involvement in the severity of COVID-19. |
| Databáze: | Directory of Open Access Journals |
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