Human transmissible spongiform encephalopathy: Case report

Autor:	Duque Velásquez, Camilo, Garzón Álzate, Ánderson, Villegas Lanau, Andrés, Escobar Velásquez, Laura Marcela, Zea Lopera, Julián, Lopera, Francisco, Rodas González, Juan David
Jazyk:	Spanish; Castilian
Rok vydání:	2014
Předmět:	Creutzfeldt-Jakob Disease Immunohistochemistry Prion Diseases Spongiosis Western Blot Enfermedad de Creutzfeldt-Jakob Enfermedad por Priones Espongiosis Inmuno-Histoquímica Medicine Medicine (General) R5-920
Zdroj:	Iatreia, Vol 27, Iss 3, Pp 330-336 (2014)
Druh dokumentu:	article
ISSN:	0121-0793 2011-7965
Popis:	We report the case of a 64 year-old woman with motor and cognitive deterioration that progressed rapidly during eight months. She was unsuccessfully treated with quinacrine, and died in a terminal status, by septic shock secondary to bronchopneumonia by broncho-aspiration. The brain was donated for research and the histopathological analysis showed spongiform changes, astrogliosis and prion protein (PrPRes) deposits, confirmed by Western blot (WB). These features are considered characteristic of prion diseases, which are uncommon in Colombia. We highlight that its diagnosis was made for the first time in this country by the simultaneous use of immunohistochemistry and Western blot.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/64e3c3004f1448189c4f9daf0960185e Zobrazit plný text záznamu View record in DOAJ