Pulmonary arterial hypertension and atrial arrhythmias: incidence, risk factors, and clinical impact

Autor: Valentina Mercurio, Grace Peloquin, Khalil I. Bourji, Nermin Diab, Takahiro Sato, Blessing Enobun, Traci Housten-Harris, Rachel Damico, Todd M. Kolb, Stephen C. Mathai, Ryan J. Tedford, Carlo G. Tocchetti, Paul M. Hassoun
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Pulmonary Circulation, Vol 8 (2018)
Druh dokumentu: article
ISSN: 2045-8940
20458940
DOI: 10.1177/2045894018769874
Popis: Atrial arrhythmia (AA) occurrence in pulmonary arterial hypertension (PAH) may determine clinical deterioration and affect prognosis. In this study we assessed AA incidence in idiopathic (IPAH) and systemic sclerosis related PAH (SSc-PAH) and evaluated risk factors, management, and impact on mortality. We collected baseline data from consecutive IPAH or SSc-PAH patients prospectively enrolled in the Johns Hopkins Pulmonary Hypertension Registry between January 2000 and July 2016. During follow-up AA onset, treatment, and outcome were recorded. Among 317 patients (201 SSc-PAH, 116 IPAH), 42 developed AA (19 atrial fibrillation, 10 flutter-fibrillation, 9 atrial flutter, and 4 atrial ectopic tachycardia) with a 13.2% cumulative incidence. Most events were associated with hospitalization (90.5%). Electrical or pharmacological cardioversion was attempted in most cases. Patients with AA had higher right atrial pressure, pulmonary wedge pressure ( P
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