Research Progress of Circular RNA in Lung Cancer
| Autor: | Yinyu MU, Fuyi XIE |
|---|---|
| Jazyk: | čínština |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Chinese Journal of Lung Cancer, Vol 21, Iss 7, Pp 543-546 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1009-3419 1999-6187 |
| DOI: | 10.3779/j.issn.1009-3419.2018.07.07 |
| Popis: | Lung cancer is one of the most important malignant tumors of human health and life in the world, and is the leading cause of death in the world. At present, it is believed that it is caused by many factors. Circular RNA (circRNA), as a class of non-coding RNA family, has covalently closed loop structure. CircRNA is abundant in different cells. CircRNAs due to the special structure, with a high degree of specificity, conservation and stability, may have a potential clinical value in the development of lung cancer. The biological function of circRNA is multi-faceted, including miRNA sponge, transcriptional and alternative splicing, protein coding , and so on. Currently, the role and mechanism of circRNA in lung cancer is not very clear. In this paper, the characteristics, function, mechanism and the role of circRNAs in the occurrence and development of lung cancer are reviewed. |
| Databáze: | Directory of Open Access Journals |
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