The Role of Adjunctive Therapies in Septic Shock by Gram Negative MDR/XDR Infections

Autor: Stefano Busani, Erika Roat, Giulia Serafini, Elena Mantovani, Emanuela Biagioni, Massimo Girardis
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 2017 (2017)
Druh dokumentu: article
ISSN: 1712-9532
1918-1493
DOI: 10.1155/2017/2808203
Popis: Patients with septic shock by multidrug resistant microorganisms (MDR) are a specific sepsis population with a high mortality risk. The exposure to an initial inappropriate empiric antibiotic therapy has been considered responsible for the increased mortality, although other factors such as immune-paralysis seem to play a pivotal role. Therefore, beyond conventional early antibiotic therapy and fluid resuscitation, this population may benefit from the use of alternative strategies aimed at supporting the immune system. In this review we present an overview of the relationship between MDR infections and immune response and focus on the rationale and the clinical data available on the possible adjunctive immunotherapies, including blood purification techniques and different pharmacological approaches.
Databáze: Directory of Open Access Journals
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