Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018
| Autor: | Siddharth Sridhar, Vincent C.C. Cheng, Shuk-Ching Wong, Cyril C.Y. Yip, Shusheng Wu, Anthony W.I. Lo, Kit-Hang Leung, Winger W.N. Mak, Jianpiao Cai, Xin Li, Jasper F.W. Chan, Susanna K.P. Lau, Patrick C.Y. Woo, Wai-Ming Lai, Tze-Hoi Kwan, Timmy W.K. Au, Chung-Mau Lo, Sally C.Y. Wong, Kwok-Yung Yuen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Emerging Infectious Diseases, Vol 25, Iss 3, Pp 425-433 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1080-6040 1080-6059 |
| DOI: | 10.3201/eid2503.181563 |
| Popis: | Hepatitis E virus (HEV) genotype 4 (HEV-4) is an emerging cause of acute hepatitis in China. Less is known about the clinical characteristics and natural history of HEV-4 than HEV genotype 3 infections in immunocompromised patients. We report transmission of HEV-4 from a deceased organ donor to 5 transplant recipients. The donor had been viremic but HEV IgM and IgG seronegative, and liver function test results were within reference ranges. After a mean of 52 days after transplantation, hepatitis developed in all 5 recipients; in the liver graft recipient, disease was severe and with progressive portal hypertension. Despite reduced immunosuppression, all HEV-4 infections progressed to persistent hepatitis. Four patients received ribavirin and showed evidence of response after 2 months. This study highlights the role of organ donation in HEV transmission, provides additional data on the natural history of HEV-4 infection, and points out differences between genotype 3 and 4 infections in immunocompromised patients. |
| Databáze: | Directory of Open Access Journals |
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