| Autor: |
Shefali Chaudhary, Sadhana Kumari, S. Senthil Kumaran, Vinay Goyal, Suman Jain, G.S. Kaloiya |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Magnetic Resonance Open, Vol 10, Iss , Pp 100050- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-4410 |
| DOI: |
10.1016/j.jmro.2022.100050 |
| Popis: |
Parkinson's Disease (PD) is a heterogenous, neurodegenerative disease with distinct pathophysiological progression. Symptom specific biomarkers may help in early diagnosis, differentiating PD subgroups and in identifying early changes associated with cognitive impairment, dementia and common non-motor symptoms. The in-vitro and in-vivo magnetic resonance spectroscopy techniques allow comprehensive, non-invasive characterization of bio-fluids (urine and saliva) and metabolic alterations and provide information on disease pathophysiology. This review summarizes the cerebral metabolic alterations and signature changes in bio-fluids in PD in comparison to controls, assessed by magnetic resonance techniques. The alterations in brain metabolites attributed to non-motor symptoms in PD with emphasis on cognitive impairment are also presented. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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