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Qirong Li,1,2,* Xinyi Zhang,2,* Qiang Feng,2,* Hengzong Zhou,2,* Chaoyang Ma,3 Chao Lin,4 Dongxu Wang,2 Jianmei Yin1 1Department of Otolaryngology-Head and Neck Surgery, the First Hospital of Jilin University, Changchun, People’s Republic of China; 2Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, People’s Republic of China; 3Hepatology Hospital of Jilin Province, Changchun, People’s Republic of China; 4School of Grain Science and Technology, Jilin Business and Technology College, Changchun, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dongxu Wang; Jianmei Yin, Email wang_dong_xu@jlu.edu.cn; yinjianmei1985@jlu.edu.cnAbstract: Allergic rhinitis (AR) is a chronic allergic disease of the upper respiratory system that affects approximately 10– 40% of the global population. Due to the large number of plant pollen allergens with obvious seasonal variations, AR is common in China. AR is primarily caused by the abnormal regulation of the immune system. Its pathophysiological mechanism involves a series of immune cells and immune mediators, including cytokines. The present review summarizes the common allergens in China and the complex pathophysiological mechanism of AR. Additionally, host allergen contact, signal transduction, immune cell activation, cytokine release, and a series of inflammatory reactions are described according to their sequence of occurrence.Keywords: allergic rhinitis, host immune response, immunoglobulin E, histamine, inflammation |
