WAYS OF IMPROVEMENT OF PHARMACOTHERAPY OF EPILEPSY AT CHILDREN: FOCUS ON SPECIFIC FEATURES OF BIOTRANSFORMATION MEDICINES

Autor:	B. I. Kantemirova, A. K. Starodubtsev, D. A. Sychev, V. V. Belopasov, Zh. M. Tsotsonava, V. I. Griganov
Jazyk:	ruština
Rok vydání:	2016
Předmět:	biotransformation children cytochrome p 450 isoenzymes epilepsy pharmacotherapy improvement ethnic pharmacogenetics Neurology. Diseases of the nervous system RC346-429
Zdroj:	Эпилепсия и пароксизмальные состояния, Vol 4, Iss 3, Pp 14-18 (2016)
Druh dokumentu:	article
ISSN:	2077-8333 2311-4088
Popis:	For the first time at children of five various nationalities living in the territory of the Astrakhan region, polymorphism of a gene of CYP2C19 on a polymorphic marker of G681A is studied. Statistically authentic distinction in frequencies of occurrence of genotypes of CYP2C19 associated both with fast, and with a slow metabolism of medicinal means substrata that testifies to importance of individual studying of polymorphism of CYP2C19 is revealed. It is studied, on restored glutathione blood, activity of the second phase of biotransformation of anti-epileptic preparations. Offers on improvement of pharmacotherapy of epilepsy at children are created.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/6499ece76fda423787eefc6eab5b2dfe Zobrazit plný text záznamu View record in DOAJ