Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

Autor: Joonas A. Jamsen, Akira Sassa, David D. Shock, William A. Beard, Samuel H. Wilson
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-21354-6
Popis: How DNA polymerases discriminate against oxidized and undamaged nucleotides during DNA repair is not fully understood. Here, the authors reveal high-resolution timelapse X-ray crystallography snapshots of DSB repair polymerase μ undergoing DNA synthesis providing mechanistic insights into the process.
Databáze: Directory of Open Access Journals