| Autor: |
Heng-Keat Tam, Wuen Ee Foong, Christine Oswald, Andrea Herrmann, Hui Zeng, Klaas M. Pos |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-021-24151-3 |
| Popis: |
Gram-negative bacteria can display intrinsic antibiotic resistance due to the action of tripartite efflux pumps, which include a H+/drug antiporter component. Here, the authors present a structure-function analysis of antiporter AcrB in intermediate states of the transport cycle, showing novel drug-binding sites and transport pathways. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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