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Hao Zou,1 Jianrong Liu,1 Dongxu Jiang,2 Linlin Hou,3 Weiliang Wang,4 Linlin Zhang5 1Nursing Department, The Second Affiliated Hospital of Xi’an Medical University, Shanxi, People’s Republic of China; 2Department of Nursing, Harbin Medical University, Heilongjiang, People’s Republic of China; 3Nursing Department, The second Affiliated Hospital of Xi’an Jiaotong University, Shanxi, People’s Republic of China; 4Nursing Department, Xuzhou Medical university, Jiangsu, People’s Republic of China; 5Department of Nursing, School of Pharmacy, Changzhou University, Jiangsu, People’s Republic of ChinaCorrespondence: Jianrong Liu; Linlin Zhang, Email 1548708192@qq.com; zhanglinlin1971@163.comPurpose: To test a hypothetical pathway model to estimate the links between health literacy, social support, illness perception, and disease management self-efficacy.Methods: This cross-sectional study, conducted from June to October 2022, involved the recruitment of 210 patients with chronic diseases at two primary care facilities. Participants completed the Health Literacy Management Scale, Self-Efficacy for Managing Chronic Disease 6-Item Scale, Social Support Rating Scale and Brief Illness Perception Questionnaire. We used the PROCESS macro for R to determine the hypothetical pathway model.Results: The direct effect of health literacy on self-efficacy was significant (β=0.1792, 95% CI: 0.0940– 0.2644), and social support played a partial mediating role between health literacy and self-efficacy (ES=0.0761, 95% CI: 0.0398– 0.1204). Illness perception moderated the relationship between social support and self-efficacy (β=− 0.0153, 95% CI: − 0.0268- − 0.0039).Conclusion: Proposed a conceptual model including the mediating effect of social support and the moderating effect of illness perception, which helps to clarify the underlying mechanisms between health literacy and self-efficacy.Keywords: health literacy, self efficacy, moderated mediation analysis |