Flt3 Regulation in the Mononuclear Phagocyte System Promotes Ocular Neovascularization
Autor: | Yushuo Gao, Yisheng Zhong, Yanji Zhu, Anna M. Demetriades, Yujuan Cai, Jikui Shen, Qing Lu, Xi Shen, Bing Xie |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: | |
Zdroj: | Journal of Ophthalmology, Vol 2018 (2018) |
Druh dokumentu: | article |
ISSN: | 2090-004X 2090-0058 |
DOI: | 10.1155/2018/2518568 |
Popis: | Fms-like tyrosine kinase 3 (Flt3), a tyrosine kinase receptor expressed in CD34+ hematopoietic stem/progenitor cells, is important for both normal myeloid and lymphoid differentiation. It has been implicated in mice and humans for potential multilineage differentiation. We found that mice deficient in Flt3 or mice that received an Flt3 inhibitor (AC220) showed significantly reduced areas of ischemia-induced retinal neovascularization (RNV) and laser-induced choroidal NV (CNV) (P |
Databáze: | Directory of Open Access Journals |
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