Flt3 Regulation in the Mononuclear Phagocyte System Promotes Ocular Neovascularization

Autor: Yushuo Gao, Yisheng Zhong, Yanji Zhu, Anna M. Demetriades, Yujuan Cai, Jikui Shen, Qing Lu, Xi Shen, Bing Xie
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Ophthalmology, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 2090-004X
2090-0058
DOI: 10.1155/2018/2518568
Popis: Fms-like tyrosine kinase 3 (Flt3), a tyrosine kinase receptor expressed in CD34+ hematopoietic stem/progenitor cells, is important for both normal myeloid and lymphoid differentiation. It has been implicated in mice and humans for potential multilineage differentiation. We found that mice deficient in Flt3 or mice that received an Flt3 inhibitor (AC220) showed significantly reduced areas of ischemia-induced retinal neovascularization (RNV) and laser-induced choroidal NV (CNV) (P
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