The FAGenomicH project: towards a whole candidate gene approach to identify markers associated with fatness and production traits in pigs and investigate the pig as a model for human obesity
| Autor: | Vincenzo Russo, Rita Casadio, Giovanni Romeo, Manuela Vargiolu, Elena Bonora, Daniela Giovanna Calò, Giuliano Galimberti, Lucia Tognazzi, Camilla Speroni, Emilio Scotti, Michela Colombo, Raffaele Fronza, Luca Fontanesi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Italian Journal of Animal Science, Vol 8, Iss 2s, Pp 87-89 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1594-4077 1828-051X |
| DOI: | 10.4081/ijas.2009.s2.87 |
| Popis: | Fatness in pigs is a complex trait for which a large number of genes are expected to be involved. Genetics of human obesity could take advantages from genetic information coming from the pig and vice versa. To these aims, a comprehensive candidate gene approach could be helpful. We catalogued all genes affecting fatness on both species, and identified in silico and by resequencing porcine SNPs on a large number of candidate genes. In addition, we applied a selective genotyping approach to identify markers associated with fat deposition in pigs. This approach was tested genotyping the IGF2 intron3-g.3072G>A mutation and novel markers in the PCSK1 and TBC1D1 genes. Polymorphisms in these genes resulted associated with back fat thickness in Italian Large White pigs. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|