Effect of Spiny-Cheek Crayfish (Faxonius limosus) on H2O2-Induced Oxidative Stress in Normal Fibroblast Cells

Autor: Klara Zglińska, Sławomir Jaworski, Anna Rygało-Galewska, Andrzej Łozicki, Mateusz Roguski, Magdalena Matusiewicz, Tomasz Niemiec
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Applied Sciences, Vol 12, Iss 17, p 8546 (2022)
Druh dokumentu: article
ISSN: 2076-3417
DOI: 10.3390/app12178546
Popis: Faxonius limosus (spiny-cheek) crayfish is an invasive species that is widespread in Europe. The aim of the study was to evaluate the possibility of using extracts from this crustacean as a source of natural antioxidants. For this purpose, selected bioactive compounds (total phenols, glutathione, vitamins A, E, D, β-carotene and amino acids) were characterised and the antioxidant activity of the extract was assessed in vitro and in relation to HFFF-2 fibroblast cells, in which oxidative stress was caused by the additive hydrogen peroxide (H2O2). The extract abolished the cytotoxicity of H2O2, decreased reactive oxygen species (ROS) secretion, increased cell viability and decreased the expression of caspase-3. The results suggest that F. limosus extract is a promising raw material with antioxidant properties.
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