Postoperative Mycobacteroides abscessus subsp. abscessus endophthalmitis: Clinical analysis of 12 clustered adults and a proposed therapeutic algorithm

Autor: Jia-Horung Hung, Wen-Chien Ko, Chau-Yin Chen, Sheng-Hsiang Lin, Cheng-Lin Wu, Sheng-Min Hsu, Yu-Ti Teng, Shih-Hao Wang, Sung-Huei Tseng, Fu-Chin Huang, Chun-Chieh Lai, Ching-Lung Chen, Chien-Hsiung Lai, Po-Lin Chen, Evelyn Jou-Chen Huang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Microbiology, Immunology and Infection, Vol 53, Iss 5, Pp 766-777 (2020)
Druh dokumentu: article
ISSN: 1684-1182
DOI: 10.1016/j.jmii.2018.12.011
Popis: Purpose: Postoperative endophthalmitis caused by nontuberculous mycobacterium is a rare but devastating complication after intraocular surgery. However, optimal treatment strategies remain undetermined in view of its rarity. Methods: We investigated the cases of culture-proven postoperative Mycobacteroides abscessus subsp. abscessus endophthalmitis in southern Taiwan, focusing on clinical manifestations and microbiological study, and aimed to describe clinical staging and to propose a therapeutic modality for this disease. Results: Twelve cases, including two published cases, were treated in two medical centers in southern Taiwan between Aug. 2011 and Dec. 2016, and all ever received cataract surgery at one clinic. Their disease courses could be categorized into four distinct stages, i.e., the initial, quiescent, recurrent, and end stage, and some cases experienced 1–4 cycles of quiescent-recurrent stages. Although all eyes ended up with phthisis or were eviscerated, the affected eyes receiving pars plana vitrectomy (PPV) tended to become quiescent and survived longer than those without PPV (adjusted hazard ratio: 13.9, p
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