Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity

Autor:	Jérôme Lacombe, Muriel Brengues, Alain Mangé, Céline Bourgier, Sophie Gourgou, André Pèlegrin, Mahmut Ozsahin, Jérôme Solassol, David Azria
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Radiotherapy Normal tissue radiotoxicity AK2 Radiation-induced breast fibrosis Radiosensitivity Proteomics Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Radiation Oncology, Vol 14, Iss 1, Pp 1-11 (2019)
Druh dokumentu:	article
ISSN:	1748-717X
DOI:	10.1186/s13014-019-1351-8
Popis:	Abstract Background Biomarkers for predicting late normal tissue toxicity to radiotherapy are necessary to personalize treatments and to optimize clinical benefit. Many radiogenomic studies have been published on this topic. Conversely, proteomics approaches are not much developed, despite their advantages. Methods We used the isobaric tags for relative and absolute quantitation (iTRAQ) proteomic approach to analyze differences in protein expression levels in ex-vivo irradiated (8 Gy) T lymphocytes from patients with grade ≥ 2 radiation-induced breast fibrosis (grade ≥ 2 bf+) and patients with grade
Databáze:	Directory of Open Access Journals
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