Microenvironmental dynamics of diabetic wounds and insights for hydrogel-based therapeutics

Autor: Ying Zhao, Yulan Zhao, Bing Xu, Hongwei Liu, Qiang Chang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Tissue Engineering, Vol 15 (2024)
Druh dokumentu: article
ISSN: 2041-7314
20417314
DOI: 10.1177/20417314241253290
Popis: The rising prevalence of diabetes has underscored concerns surrounding diabetic wounds and their potential to induce disability. The intricate healing mechanisms of diabetic wounds are multifaceted, influenced by ambient microenvironment, including prolonged hyperglycemia, severe infection, inflammation, elevated levels of reactive oxygen species (ROS), ischemia, impaired vascularization, and altered wound physicochemical properties. In recent years, hydrogels have emerged as promising candidates for diabetic wound treatment owing to their exceptional biocompatibility and resemblance to the extracellular matrix (ECM) through a three-dimensional (3D) porous network. This review will first summarize the microenvironment alterations occurring in the diabetic wounds, aiming to provide a comprehensive understanding of its pathogenesis, then a comprehensive classification of recently developed hydrogels will be presented, encompassing properties such as hypoglycemic effects, anti-inflammatory capabilities, antibacterial attributes, ROS scavenging abilities, promotion of angiogenesis, pH responsiveness, and more. The primary objective is to offer a valuable reference for repairing diabetic wounds based on their unique microenvironment. Moreover, this paper outlines potential avenues for future advancements in hydrogel dressings to facilitate and expedite the healing process of diabetic wounds.
Databáze: Directory of Open Access Journals
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