Gene expression of Nectin‐4 and its clinical significance in dogs with primary lung adenocarcinoma

Autor: Kei Tamura, Kumiko Ishigaki, Orie Yoshida, Terai Kazuyuki, Naoki Sakurai, Tatsuya Heishima, Tomoko Fujiyuki, Chieko Kai, Kazushi Asano
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Veterinary Medicine and Science, Vol 8, Iss 5, Pp 1922-1929 (2022)
Druh dokumentu: article
ISSN: 2053-1095
DOI: 10.1002/vms3.895
Popis: Abstract Background Canine primary lung adenocarcinoma (CPLA) is suspected by radiography or computed tomography; however, since there are no tumour markers, early diagnosis is difficult, and the prognosis is poor due to increased tumour volume. Nectin‐4 has been reported to be expressed in human lung, ovarian, and pancreatic cancers and promotes tumour growth. It has been reported to be a tumour marker and prognostic factor, and oncolytic virotherapy is being investigated using nectin‐4 as a therapeutic target. Objectives The purpose of this study was to investigate the expression of Nectin‐4 in CPLA and its clinical significance in dogs with pulmonary adenocarcinomas. Methods The relationships between Nectin‐4 expression and signalling, tumour volume, tumour weight, and prognosis were analyzed in 34 CPLA patients. Results The expression of canine Nectin‐4 (high Nectin‐4) was found in 25 of 34 cases (73%), and Nectin‐4 expression levels did not show any significant associations with gender, body weight, and tumour stage. However, there was a significant positive correlation between Nectin‐4 expression and tumour volume (r = 0.623, p
Databáze: Directory of Open Access Journals
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