Janus kinase 2 V617F mutation in an unrelated peripheral blood stem cell donor
| Autor: | Shang-Hsien Yang, Hsiang-Lin Wan, Ming-Hui Gu, Tso-Fu Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Tzu-Chi Medical Journal, Vol 31, Iss 1, Pp 60-62 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1016-3190 2223-8956 |
| DOI: | 10.4103/tcmj.tcmj_189_17 |
| Popis: | Polycythemia vera (PV) is relatively uncommon in early adulthood, and evidence about the prevalence of the Janus kinase 2 (JAK2) V617F mutation in the general population is limited. Here, we report a previously healthy volunteer peripheral blood stem cell (PBSC) donor who developed symptomatic PV with the JAK2 V617F mutation 2 years after PBSC mobilization and harvest. The characteristic mutation was identified retrospectively in the blood sample of the donor at the confirmation typing stage, which was before granulocyte colony-stimulating factor injection. This report presents a safety issue for both donor and recipient of hematopoietic stem cell transplantation. Clinicians should be aware of this during health workup and postdonation follow-up of unrelated PBSC donors. Any abnormal and/or equivocal laboratory data, especially during the donor workup stage, should not be overlooked. |
| Databáze: | Directory of Open Access Journals |
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