FT-IR Spectroscopy for the Detection of Diethylene Glycol (DEG) Contaminant in Glycerin-Based Pharmaceutical Products and Food Supplements
| Autor: | Ayman Y Hammoudeh, Safwan M Obeidat, Eman Kh Abboushi, Amal M Mahmoud |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Acta Chimica Slovenica, Vol 67, Iss 2, Pp 530-536 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1318-0207 1580-3155 |
| DOI: | 10.17344/acsi.2019.5553 |
| Popis: | Identification and determination of diethylene glycol (DEG) in glycerin-based products was successfully achieved using FT-IR spectroscopy. Studied samples included 0.5% to 20% by mass DEGspiked into cough syrup, two paracetamol syrup formulations, and two food supplements. The characteristic DEGwavenumbers at 881 cm-1 and 1083 cm-1 were used for its quantitative determination in the studied samples. A very good accuracy in determining the DEG fraction was achieved with a mean error% of ±2.02% to ±7.69% upon using the corrected absorbance at 881 cm-1. The corrected absorbance at 1083 cm-1 band was used in the case of paracetamol formulations and resulted in a mean error% ranging from ±2.50% to ±10.28%. The values of limit of detection of the current method ranged from 0.051% to 0.068% DEG for all studied samples. |
| Databáze: | Directory of Open Access Journals |
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