Pulmonary Toxicity of Bleomycin – A Case Series from a Tertiary Care Center in Southern India
| Autor: | NAVIN PATIL, RINZ MATHEW PAULOSE, KARTHIK SUBRAMANYA UDUPA, NARAYANAN RAMAKRISHNA, TALHA AHMED |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 10, Iss 4, Pp FR01-FR03 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X |
| DOI: | 10.7860/JCDR/2016/18773.7626 |
| Popis: | Hodgkin’s lymphoma is one of the curable cancers and the standard treatment regimen involves combination chemotherapy involving bleomycin. One of the fatal side effect of bleomycin is pulmonary toxicity. Here we present three cases of Hodgkin’s lymphoma treated with ABVD chemotherapy who had pulmonary toxicity. All three developed bleomycin induced pulmonary toxicity in the form of pulmonary fibrosis during treatment of the disease. Mode of treatment, severity of the condition and the treatment outcome varied among the three. Two recovered following treatment and one patient died due to irreversible pulmonary damage. Causality assessment using Naranjo’s scale gave a score of 7 for case one and three and a score of 6 for case two, both indicating the adverse drug reaction to be a probable bleomycin induced Lung fibrosis. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|