Desorption chemical ionization mass spectrometry of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholines and analogues.

Autor: M J Thomas, M Samuel, R L Wykle, J R Surles, C Piantadosi
Jazyk: angličtina
Rok vydání: 1986
Předmět:
Zdroj: Journal of Lipid Research, Vol 27, Iss 2, Pp 172-176 (1986)
Druh dokumentu: article
ISSN: 0022-2275
DOI: 10.1016/S0022-2275(20)38847-7
Popis: Ammonia desorption chemical ionization of ether-linked phospholipids of the type 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (platelet-activating factors) and a series of analogues revealed a systematic fragmentation pattern that is characteristic for these compounds. The predominant ions included the protonated molecular ion and a series of fragments derived from the molecular ion having the following nominal mass losses: MH-14, MH-42, MH-59, and MH-183. Deuterated ammonia was used to elucidate the nature of several fragments. In addition, desorption chemical ionization was used to quantitate 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine at the nanogram/sample level.
Databáze: Directory of Open Access Journals