Impact of Roux-en-Y gastric bypass on lipid and inflammatory profiles
| Autor: | Cleiton da Silva Oliveira, Bruna Teles Soares Beserra, Raphael Salles Granato Cunha, Ana Gabriela Estevam Brito, Rafaella Cristina Dimbarre de Miranda, Lúcia Andréia Zanette Ramos Zeni, Everson Araújo Nunes, Erasmo Benicio Santos de Moraes Trindade |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Předmět: | |
| Zdroj: | Revista do Colégio Brasileiro de Cirurgiões, Vol 42, Iss 5, Pp 305-310 |
| Druh dokumentu: | article |
| ISSN: | 1809-4546 0100-6991 |
| DOI: | 10.1590/0100-69912015005007 |
| Popis: | Objective: To evaluate the behavior of acute phase proteins and lipid profile in patients undergoing Roux-en-Y gastric bypass. Methods : We conducted a prospective study, consisting of three moments: M1 - preoperative (24 hours before surgery); M2 - 30 days after surgery; and M3 - 180 days after surgery. We carried measured height and BMI, as well as determined the concentrations of acute phase proteins (C-reactive protein (CRP), albumin and Alpha-1-acid glycoprotein) and total cholesterol, LDL-c, HDL-c and triacylglycerol. Results : participants comprised 25 individuals, with a mean age of 39.28 ± 8.07, 72% female. At all times of the study there was statistically significant difference as for weight loss and BMI. We found a significant decrease in CRP concentrations between the moments M1 and M3 (p = 0.041) and between M2 and M3 (p = 0.018). There was decrease in Alpha-1-GA concentrations between M1 and M2 (p = 0.023) and between M1 and M3 (p = 0.028). The albumin values increased, but did not differ between times. Total cholesterol and triacylglycerol decreased significantly ay all times. LDL-c concentrations decreased and differed between M1 and M2 (p = 0.001) and between M1 and M3 (p = 0.001). HDL-c values increased, however only differing between M1 and M2 (p = 0.050). Conclusion : Roux-en-Y gastric bypass promoted a decrease in plasma concentrations of CRP and Alpha-1-acid glycoprotein, improving lipid and inflammatory profiles. |
| Databáze: | Directory of Open Access Journals |
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