| Autor: |
Nikolaj W. Ørntoft, Lars C. Gormsen, Susanne Keiding, Ole L. Munk, Peter Ott, Michael Sørensen |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
JHEP Reports, Vol 3, Iss 3, Pp 100288- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2589-5559 |
| DOI: |
10.1016/j.jhepr.2021.100288 |
| Popis: |
Background & Aims: It is not known how hepatic bile acids transport kinetics changes postprandially in the intact liver. We used positron emission tomography (PET)/computed tomography (CT) with the tracer [N-methyl-11C]cholylsarcosine (11C-CSar), a synthetic sarcosine conjugate of cholic acid, to quantify fasting and postprandial hepatic bile acid transport kinetics in healthy human participants. Methods: Six healthy human participants underwent dynamic liver 11C-CSar PET/CT (60 min) during fasting and from 15 min after ingestion of a standard liquid meal. Hepatobiliary secretion kinetics of 11C-CSar was calculated from PET data, blood samples (arterial and hepatic venous) and hepatic blood flow measured using indocyanine green infusion. Results: In the postprandial state, hepatic blood perfusion increased on average by 30% (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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