Genomic characterization of velogenic avian orthoavulavirus 1 isolates from poultry workers: Implications to emergence and its zoonotic potential towards public health
| Autor: | Muhammad Zubair Shabbir, Ruth Helmus Nissly, Abdul Ahad, Masood Rabbani, Levina Lim, Shubhada K Chothe, Murugan Subbiah, Aswathy Sebastian, Istvan Albert, Aziz Ul-Rahman, Bhushan M Jayarao, Suresh V Kuchipudi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Asian Pacific Journal of Tropical Medicine, Vol 14, Iss 2, Pp 64-72 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2352-4146 1995-7645 |
| DOI: | 10.4103/1995-7645.306762 |
| Popis: | Objective: To carry out the genetic characterization and evolutionary analysis of three avian orthoavulavirus 1 (AOAV-1) isolates from poultry workers with respiratory symptoms. Methods: Using Illumina MiSeq, whole-genome sequencing was carried out to assess the evolutionary dynamics of three AOAV-1 isolates. A phylogenetic and comparative analysis of all coding genes was done using bioinformatics tools. Results: Phylogenetic analysis and genetic distance estimation suggested a close relationship among human- and avian-originated velogenic strains of genotype XIII, sub-genotype XIII.2.1. Several substitutions in the significant structural and biological motifs were exclusively identified in the human-originated strains. Conclusions: To our knowledge, this is the first report of a velogenic AOAV-1 isolate from natural infection of the human upper respiratory tract. Our findings highlight the evolution and zoonotic potential of velogenic AOAV-1 in a disease endemic setting. |
| Databáze: | Directory of Open Access Journals |
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