Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

Autor: Zhenhao Fang, Lei Peng, Renata Filler, Kazushi Suzuki, Andrew McNamara, Qianqian Lin, Paul A. Renauer, Luojia Yang, Bridget Menasche, Angie Sanchez, Ping Ren, Qiancheng Xiong, Madison Strine, Paul Clark, Chenxiang Lin, Albert I. Ko, Nathan D. Grubaugh, Craig B. Wilen, Sidi Chen
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-30878-4
Popis: Here the authors show that Omicron neutralizing antibody titers decline over time in mice immunized with a wild-type (WT) lipid nanoparticle (LNP)-mRNA vaccine and are robustly increased by WT or Omicron LNP-mRNA and that Omicron boosters elicit higher BA.1-neutralizing titer than WT boosters.
Databáze: Directory of Open Access Journals